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2023.02 Hyperammonemia (Urea cycle disorders PLUS) Online Course

Class Description

February 27 - March 10, 2023

Price: $free for physicians & trainees, nurse/nurse practitioners, physician associates, genetic counselors, dietitians, others: $100 corporate applicants

Approved for 7.0 AMA PRA Category. 1 Credits™/ 7.0 AAPA Category 1 CME credits/ 7.0 ANCC Contact Hours/ 7.0 Credits for Dieticians


This online course is spread out over two weeks to accommodate a full-time working schedule. It includes a mix of learning experiences - six short live sessions (with a choice of 9:00am or 5:00pm ET), brief pre-recorded on-demand lecture segments to review when convenient, and homework exercises to apply the learned principles to practical, clinical situations. The curriculum also includes live patient presentations and a special session about the nutritional perspective regarding management. The duration of the course allows a comprehensive overview of the topic with repeat opportunities to review and master the concepts.

The course targets primarily (but not exclusively) advanced practice providers and clinicians who:

  • have a science background
  • have had no/limited formal training in genetic metabolic disease
  • are interested, or are involved, in the diagnosis/management of patients with inborn errors of metabolism

Nurses/nurse practitioners, physician associates, genetic counselors, and dietitians, and their trainees, are especially welcome, but physicians, as well as research and corporate applicants, are invited to participate as well.


  • Mark Korson, MD
  • Leslie Martell, MS, RD, LDN
  • Patient-teacher(s), to be announced


At the end of each training, attendees should be able to:

  1. Detail the varied phenotypes of the urea cycle disorders, and provide a general overview of diseases that cause a secondary hyperammonemia
  2. Review the disease physiology and link it to the clinical and biochemical phenotypes.
  3. Characterize the biochemical derangements that typify primary and secondary hyperammonemia and how they apply to diagnosis and therapeutic monitoring.
  4. Employ current guidelines for the diagnosis and management of patients with urea cycle disorders and secondary causes of hyperammonemia.
  5. Formulate in conjunction with other team members specific assessments and care-plans of patients with suspected or proven urea cycle disorders and secondary causes of hyperammonemia.


Each course is spaced out over two weeks to support working schedules and enhance recall. Learning occurs from short, on-demand video lecture segments (~20 minutes), homework cases, and live sessions to review the homework and hear from patients/a metabolic dietitian. Live sessions are offered at 9am and 5pm ET; you register for either track but know that you can easily switch from one to the other, depending on your schedule. After you register, you will be provided login information to access a restricted webpage that will house all the documents, links, videos, and materials for the course. Participants can download a syllabus of all lecture segments. Following the course, participants are eligible to participate in follow-up review questions/cases, if they wish additional practice around what they learned.

Week One

  • Topics discussed - Physiology, Biochemistry, Clinical Phenotype, Genetics, Diagnostic testing, Newborn screening
  • Homework – recorded sessions, questions and cases
  • Live sessions - Monday, Wednesday, Friday (9am or 5pm ET) – review homework

Week Two

  • Topics discussed - Management
  • Homework – recorded sessions, questions and cases
  • Live sessions - Monday, Wednesday, Friday (9am or 5pm ET) – review homework, patient presentations, nutrition presentation


  1. The topics are relevant.
  2. The presentation is pitched appropriately for the audience.
  3. The format is clinical and practical.
  4. Where possible, the patient story is included in the program (live +/- recorded presentations).
  5. Teaching is interactive and includes engaging the audience throughout with questions and case reviews.
  6. Through a combination of didactic teaching and case workshops, attendees are given the opportunity to apply the principles they have learned to (adapted) real-life cases, empowering them to better tackle such medical challenges in their clinical practice
  7. Repeated learning over time is more likely to be associated with a long-term retention of the material.
  8. All essential teaching slides are provided in a handout to attendees.


Continuing Education Credits:

Joint Accreditation Statement  Jointly Accreditated Provider.jpgIn support of improving patient care, this activity has been planned and implemented by the Postgraduate Institute for Medicine and Virtual Medical Practice.  Postgraduate Institute for Medicine is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education  The Postgraduate Institute for Medicine designates this live activity for a maximum of 7.0 AMA PRA Category 1 Credit(s)™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Continuing Nursing Education  The maximum number of hours awarded for this Continuing Nursing Education activity is 7.0 contact hours.

AAPA Credit Designation Statement  AAPA CME.pngPostgraduate Institute for Medicine has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 7.0 AAPA Category 1 CME credits. PAs should only claim credit commensurate with the extent of their participation.

Continuing Dietician Education  This program offers 7.0 CPEUs for dieticians.

Computer System Requirements:

Zoom & YouTube account with access to DSL 15 Mbps or higher, Fiber, 4g, or 5g internet access. The higher the Mbps, the better quality.

Disclosure of Conflicts of Interest:

Postgraduate Institute for Medicine (PIM) requires faculty, planners, and others in control of educational content to disclose all their financial relationships with ineligible companies. All identified conflicts of interest (COI) are thoroughly vetted and mitigated according to PIM policy.  PIM is committed to providing its learners with high quality accredited continuing education activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company. The faculty reported the following relevant financial relationships with ineligible entities related to the educational content of this CE activity:

  • Mark Korson, MD has the following to report:
    • Recordati Rare Diseases, Aeglea Biotherapeutics, Travere Therapeutics - grant recipient
    • Solace Nutrition, Tessera Therapeutics, Glycomine Inc, Eton Pharmaceuticals, HemoShear Therapeutics - consultant/advisory board member
  • Leslie Martell, MS, RD, LDN: nothing to disclose.
  • Patient-teacher(s): to be announced
  • The PIM planners and managers: nothing to disclose.

Disclosure of Unlabeled Use:

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA.  The planners of this activity do not recommend the use of any agent outside of the labeled indications.  The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners.  Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development.  The information presented in this activity is not meant to serve as a guideline for patient management.  Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.


Jointly provided by Virtual Medical Practice and Postgraduate Institute for Medicine.

This activity is supported by an independent educational grant from Recordati Rare Diseases, Aeglea BioTherapeutics.

....when enrolling, please let us know if you will be attending the 9am or 5pm (ET) course. However, please note that you can switch from one to the other option freely and without notifying us.

Registration - CLOSED

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